FIRST OF ALL
Continuous Buffer Management System - Alternative to Tank Farm
Just as video streaming revolutionized how we play video, we have an inline-mixing/relay-tank based buffer prep solution with much smaller footprint. The small footprint and full S88 operation solution of the solution led to significant capital saving, operational saving, and better documentation. This unique process concept can be applied with either Single Use or Stainless Steel vessels for not only green field but also brown field projects. Attributed to innovative development in standardizing the functional modules and control strategies of the system, CBMS is a robust alternative to traditional tank farm for buffer prep area. The modular CBMS can be aligned to existing facility and has a S88 batch operation solution for multi-units on DCS platform.
Significant Saving On Capex
Lower Operating Cost
Reduced Cycle Time
Much Smaller Footprint
S88 Batch Automation
Better Documentation
M++ UltraPilot: One-Stop Tech Transfer Platform /Process Intensification (PI) for Connected and Continuous Batches
M++ UltraPilot provides a platform where R&D and Production can meet. Please check in with us for M++ UltraPilot, an ultimate process intensification (PI) and tech transfer (TT) tool with full scalability to cGMP production. M++ features multiple multifunctional flow handling units on same industrial DCS control network with S88 batch capability. Each unit is capable of running chromatography, Inline dilution (ID), TFF, NFF, SSTFF/SPTFF as well as process intensification (PI). Multi-column continuous chromatography and connected batches of multiple chromatography/filtration steps can be readily run without surge tanks in between. A typical nine batch mAb downstream process can technically be run with two or three connected batches. The impact of reduced processing time and smaller equipment footprint can't be overemphasized. Timely and economical proof of concept (POC) and tech transfer (TT) can be achieved with M++ at benchtop scale. M++ UltraPilot interfaces with enterprise recipe management (ERM/MES) and process knowledge management (PKM) with its DCS control platform and common data framework, effectively supporting process scaleup, tech transfer, and CMC data management.
cGMP Hygienic Flowpath
Chromatography/ID/IC
Better CMC Support
TFF/NFF/SSTFF/SPTFF
DCS & Batch Management
One-Stop Tech Transfer
Multi-Column Continuous Chromatography (4C)
Direct Loading of Unconditioned Feed
Benchtop/Modular
6 bar and 750 ml/min
OUR STORY


Direct Loading Of Unclarified Feed
TFF Without Tank/Load Cell/Stirrer/Spray Ball
OUR STORY
Chromatography Columns For Difficult Applications
Discover how Lisure Technology Co. revolutionizes the biopharmaceutical industry with our innovative process solutions. Columns do not have to be scaled wide anymore even for compressible media. Wall effect used to be a myth for columns larger than 300mm but not anymore. With superior HETP from newly designed bed-independent high efficiency flow distributor, chromatography columns can now be scaled up with higher bed height and same residence time (RT) principle. Much smaller columns can achieve the same productivity as large wide columns could, reducing capital investment significantly.
Lower Bed in Larger Column
No Wall Effect @>300mm
Higher Bed of Soft Media
Better Efficiency (HETP)
OUR STORY
Integrated Downstream Process - Combined Filtration and Chromatography
Find out our cutting-edge process solutions that streamline biopharmaceutical downstream processes, making them simpler and more efficient. We have combined centrifuge, depth filtration, and capture chromatography all in one elegant step. This would not be possible without key developments such as high efficiency non-clogging column, continuous foulant guard, self-enclosed recirculation mixing, and its novel process control configuration. The economical and operational benefits can not be more obvious: less capital, fewer processing steps, shorter cycle time, higher resin binding capacity, no depth filters, and fully automated.
One Step Integrating Three
Completely Enclosed Process
Shorter Cycle Time
Significant Benefits
Better HETP
Higher DBC/Less Media
OUR STORY
4C Continuous Chromatography On DCS
We made 4C continuous chromatography easy. Continuous chromatography achieves efficient and cost-saving scale-up with smaller columns and better utilization of resin. It used to be complicated to implement but we have designed specialized valve matrix and a control strategy, DCS based control solution, all ready to go


Higher DBC/Less Media
Reduced Total Cycle Time
Smaller Column & System
S88 Batch Automation
OUR STORY
Inline Dilution/Conditioning Process Chromatography (ICPC)
Trust Lisure Technology Co. to simplify your bioprocess. ICPC combines buffer prep and process chromatography in one step leading to significant capital and operational saving through its small footprint. Lisure ICPC achieves high dilution ratio through its patented mixing flow chamber design and a relay tank for critical buffer. Lisure's patented internal recirculation loop for each concentrate stream minimizes the buffer waste during system stabilization. The system has a DCS based process control strategy and can be easily integrated with plant DCS.
Chrom&Buffer Combined
Small Footprint
Minimized Buffer Waste
High Dilution Ratio
No Chromatogram Artifacts
HPLC Column and System


Discover Lisure's innovative engineering solution for challenges with HPLC columns and systems, designed specifically for purification of complex compounds such as insulin and GLP-1 peptides. Our extensive range of columns, available in sizes from 300mm to 1200mm in diameter and pressure ratings of 70bar or 100bar, ensures precise and efficient performance. We pride ourselves on offering flexible customization options to meet your specific needs. Our products are engineered for flexible operation, coupled with simple and easy maintenance, making them the perfect choice for drug manufacturers seeking reliability and ease of use in their high and medium pressure separation processes.
OUR STORY


And let's not forget
Custom Engineering And S88 Batch Automation Solution
Our team of passionate scientists and engineers, combined with experienced bioprocess solution professionals, ensures the highest quality and efficiency in building customized downstream process solutions. With our key technical competency in flow system design, high-end hardware design, control strategy design, and quality management, we provide top-notch bioprocess solutions for customers in the cGMP regulated industry. Our extensive project execution experience ensures the successful implementation of our solutions. Beyond ISO9001 certification, our adherence to industrial standards, including ASME BPE, GAMP, and ISA S88, reflects our unwavering commitment to excellence. Let us be the driving force behind your success in navigating custom engineering challenges in bioprocessing.
